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Sequential Rhodium/Palladium Catalysis: Enantioselective Formation of Dihydroquinolinones in the Presence of Achiral and Chiral Ligands
Author(s) -
Zhang Lei,
Qureshi Zafar,
Sonaglia Lorenzo,
Lautens Mark
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201407400
Subject(s) - enantioselective synthesis , rhodium , palladium , catalysis , domino , chemistry , combinatorial chemistry , ligand (biochemistry) , conjugate , stereochemistry , organic chemistry , mathematics , mathematical analysis , biochemistry , receptor
Compatible combinations of achiral and chiral ligands can be used in rhodium/palladium catalysis to achieve highly enantioselective domino reactions. The difference in rates of catalysis and minimal effects of ligand interference confer control in the domino sequence. The “all‐in‐one” 1,4‐conjugate arylation and CN cross‐coupling through sequential Rh/Pd catalysis provides access to enantioenriched dihydroquinolinone building blocks.