Crystallographic Snapshot of an Arrested Intermediate in the Biomimetic Activation of CO 2 | Zendy

Ackermann Sarah L. | Zendy; Wolstenholme David J. | Zendy; Frazee Chris | Zendy; Deslongchamps Ghislain | Zendy; Riley Sandra H. M. | Zendy; Decken Andreas | Zendy; McGrady G. Sean | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Crystallographic Snapshot of an Arrested Intermediate in the Biomimetic Activation of CO 2

Author(s) -

Ackermann Sarah L.,

Wolstenholme David J.,

Frazee Chris,

Deslongchamps Ghislain,

Riley Sandra H. M.,

Decken Andreas,

McGrady G. Sean

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201407165

Subject(s) - carbonic anhydrase , chemistry , enzyme , substrate (aquarium) , catalysis , carbonic anhydrase ii , stereochemistry , biophysics , combinatorial chemistry , biochemistry , biology , ecology

The design of molecular catalysts that mimic the behavior of enzymes is a topical field of activity in emerging technologies, and can lead to an improved understanding of biological systems. Herein, we report how the bulky arms of the cations in [( n C 4 H 9 ) 4 N] + [HCO 3 ] ‐ give rise to a host scaffold that emulates the substrate binding sites in carbonic anhydrase enzymes, affording a unique glimpse of an arrested intermediate in the base‐mediated binding and activation of CO 2 .

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research