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C(sp 3 ) 18 F Bond Formation by Transition‐Metal‐Based [ 18 F]Fluorination
Author(s) -
Liang Steven H.,
Vasdev Neil
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201407065
Subject(s) - manganese , transition metal , cobalt , chemistry , trace (psycholinguistics) , radiochemistry , inorganic chemistry , organic chemistry , catalysis , linguistics , philosophy
Without a trace? Recent advances in aliphatic radiofluorinations enabled by transition metals, specifically cobalt/salen and manganese/salen complexes, have been unveiled. These new approaches operate in a unique way which obviates the need for highly activated substrates for radiolabeling and offers a new synthetic strategy to prepare 18 F‐labeled radiotracers.