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Enantioselective Iron‐Catalyzed Intramolecular Cyclopropanation Reactions
Author(s) -
Shen JunJie,
Zhu ShouFei,
Cai Yan,
Xu Huan,
Xie XiuLan,
Zhou QiLin
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406853
Subject(s) - cyclopropanation , intramolecular force , carbenoid , enantioselective synthesis , catalysis , chemistry , combinatorial chemistry , organic chemistry , rhodium
Abstract An iron‐catalyzed asymmetric intramolecular cyclopropanation was realized in high yields and excellent enantioselectivity (up to 97 % ee) by using the iron complexes of chiral spiro‐bisoxazoline ligands as catalysts. The superiority of iron catalysts exhibited in this reaction demonstrated the potential abilities of this sustainable metal in asymmetric carbenoid transformation reactions.