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Cover Picture: Paenilamicin: Structure and Biosynthesis of a Hybrid Nonribosomal Peptide/Polyketide Antibiotic from the Bee Pathogen Paenibacillus larvae (Angew. Chem. Int. Ed. 40/2014)
Author(s) -
Müller Sebastian,
GarciaGonzalez Eva,
Mainz Andi,
Hertlein Gillian,
Heid Nina C.,
Mösker Eva,
van den Elst Hans,
Overkleeft Herman S.,
Genersch Elke,
Süssmuth Roderich D.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406846
Subject(s) - american foulbrood , nonribosomal peptide , polyketide , biology , paenibacillus , microbiology and biotechnology , virulence , pathogen , biosynthesis , bacteria , spore , 16s ribosomal rna , biochemistry , gene , genetics
American Foulbrood is a widespread and devastating disease of the honey bee brood caused by the bacterium Paenibacillus larvae. In their Communication on page 10821 ff., R. D. Süssmuth et al. elucidated a fascinating nonribosomal biosynthesis through the isolation and structure elucidation of the antibacterial and antifungal paenilamicins. Furthermore, examination of the secondary metabolites of P. larvae sheds light on the virulence mechanisms.