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Rationally Designed Multifunctional Supramolecular Iminium Catalysis: Direct Vinylogous Michael Addition of Unmodified Linear Dienol Substrates
Author(s) -
Gu Yun,
Wang Yao,
Yu TianYang,
Liang YongMin,
Xu PengFei
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406786
Subject(s) - iminium , regioselectivity , michael reaction , reactivity (psychology) , nucleophilic addition , catalysis , supramolecular chemistry , nucleophile , chemistry , combinatorial chemistry , organic chemistry , molecule , medicine , alternative medicine , pathology
The development of a direct vinylogous Michael addition of linear nucleophilic substrates is a long‐standing challenge because of the poor reactivity and the considerable difficulty in controlling regioselectivity. By employing a rationally designed multifunctional supramolecular iminium catalysis strategy, the first direct vinylogous Michael addition of unmodified linear substrates to α,β‐unsaturated aldehydes, to afford chiral 1,7‐dioxo compounds with good yields and excellent regio‐ as well as enantioselectivity, has been developed.