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Iron‐Catalyzed C(sp 2 )H Alkylation of Carboxamides with Primary Electrophiles
Author(s) -
Monks Brendan M.,
Fruchey Erin R.,
Cook Silas P.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406594
Subject(s) - alkylation , electrophile , catalysis , primary (astronomy) , alkyl , chemistry , aryl , medicinal chemistry , combinatorial chemistry , organic chemistry , computer science , physics , astronomy
The direct ortho alkylation of 8‐aminoquinoline‐based aryl amides was achieved with primary alkyl bromides in high yields in the presence of an iron catalyst, 1,2‐bis(diphenylphosphino)ethane (dppe), and PhMgBr in 2‐MeTHF.