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From the Human Genome to the Human Proteome
Author(s) -
Muñoz Javier,
Heck Albert J. R.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406545
Subject(s) - human proteome project , proteome , alternative splicing , human genome , computational biology , genome , gene , biology , gene isoform , translation (biology) , rna splicing , proteomics , genetics , rna , messenger rna
A herculean task : Determining the human proteome sets the ultimate challenge in cell biology as it is thought to consist of more than 1 000 000 proteoforms, in contrast to “only” 20 000 protein‐coding genes. Two teams of researchers have now proved the translation of 18 000 proteins (and more than 27 000 isoforms) by mass spectrometry. They obtained important information on the extent of protein translation and alternative splicing.