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Dehydrogenative N‐Incorporation: A Direct Approach to Quinoxaline N ‐Oxides under Mild Conditions
Author(s) -
Chen Feng,
Huang Xiaoqiang,
Li Xinyao,
Shen Tao,
Zou Miancheng,
Jiao Ning
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406479
Subject(s) - quinoxaline , chemistry , combinatorial chemistry , nitrite , surface modification , cleavage (geology) , bond cleavage , medicinal chemistry , transformation (genetics) , organic chemistry , catalysis , materials science , biochemistry , nitrate , fracture (geology) , composite material , gene
An efficient method for the synthesis of quinoxaline N ‐oxides proceeds by the dehydrogenative N‐incorporation of simple imines by C(sp 2 )H and C(sp 3 )H bond functionalization. The overall transformation involves the cleavage of three CH bonds. The reaction is easily handled and proceeds under mild conditions. Simple and readily available tert ‐butyl nitrite (TBN) was employed as the NO source.