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Catalytic Borylation of SCF 3 ‐Functionalized Arenes by Rhodium(I) Boryl Complexes: Regioselective CH Activation at the ortho ‐Position
Author(s) -
Kalläne Sabrina I.,
Braun Thomas
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406424
Subject(s) - borylation , regioselectivity , rhodium , chemistry , catalysis , organoboron compounds , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , aryl , alkyl
An unprecedented reaction pathway for the borylation of SCF 3 ‐containing arenes using [Rh(Bpin)(PEt 3 ) 3 ] (pin=pinacolato) is reported. Catalytic processes were developed and the functionalizations proceed under mild reaction conditions. The CH activations occur with a unique regioselectivity for the position ortho to the SCF 3 group, which apparently serves as directing group. Borylated SCF 3 compounds can serve as versatile building blocks.