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The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)
Author(s) -
Südhof Thomas C.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406359
Subject(s) - neurotransmitter , neurotransmission , synaptic vesicle , neuroscience , chemistry , vesicle , biophysics , membrane , biology , biochemistry , central nervous system , receptor
The most important property of synaptic transmission is its speed, which is crucial for the overall workings of the brain. In his Nobel Lecture, T. C. Südhof explains how the synaptic vesicle and the plasma membrane undergo rapid fusion during neurotransmitter release and how this process is spatially organized, such that opening of Ca 2+ ‐channels allows rapid translation of the entering Ca 2+ signal into a fusion event.