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Reversibly Controlling Preferential Protein Adsorption on Bone Implants by Using an Applied Weak Potential as a Switch
Author(s) -
Liao Jingwen,
Zhu Ye,
Zhou Zhengnan,
Chen Junqi,
Tan Guoxin,
Ning Chengyun,
Mao Chuanbin
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406349
Subject(s) - wetting , adsorption , amphiphile , materials science , protein adsorption , polypyrrole , biomolecule , nanotechnology , adhesion , self healing hydrogels , chemistry , chemical engineering , biophysics , polymer chemistry , copolymer , organic chemistry , polymerization , composite material , polymer , engineering , biology
A facile method is needed to control the protein adsorption onto biomaterials, such as, bone implants. Herein we doped taurocholic acid (TCA), an amphiphilic biomolecule, into an array of 1D nano‐architectured polypyrrole (NAPPy) on the implants. Doping TCA enabled the implant surface to show reversible wettability between 152° (superhydrophobic, switch‐on state) and 55° (hydrophilic, switch‐off state) in response to periodically switching two weak electrical potentials (+0.50 and −0.80 V as a switch‐on and switch‐off potential, respectively). The potential‐switchable reversible wettability, arising from the potential‐tunable orientation of the hydrophobic and hydrophilic face of TCA, led to potential‐switchable preferential adsorption of proteins as well as cell adhesion and spreading. This potential‐switchable strategy may open up a new avenue to control the biological activities on the implant surface.