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Inside Back Cover: Single‐Molecule Mechanochemical Sensing Using DNA Origami Nanostructures (Angew. Chem. Int. Ed. 31/2014)
Author(s) -
Koirala Deepak,
Shrestha Prakash,
Emura Tomoko,
Hidaka Kumi,
Mandal Shankar,
Endo Masayuki,
Sugiyama Hiroshi,
Mao Hanbin
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406158
Subject(s) - dna origami , multiplex , nanostructure , nanotechnology , cover (algebra) , dna , molecule , optical tweezers , materials science , topology (electrical circuits) , chemistry , physics , engineering , bioinformatics , biology , optics , electrical engineering , mechanical engineering , organic chemistry , biochemistry
DNA origami nanotiles have been used as novel multiplex mechanochemical sensors. In their Communication on page 8137 ff., M. Endo, H. Sugiyama, H. Mao et al. show that the binding of specific target molecules to the sensor unlocks the interconnected tiles, and the global topology of the DNA nanostructure rearranges. This process is monitored as mechanochemical signals in real time using optical tweezers.