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Inside Back Cover: Development of a 18 F‐Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging (Angew. Chem. Int. Ed. 36/2014)
Author(s) -
Denk Christoph,
Svatunek Dennis,
Filip Thomas,
Wanek Thomas,
Lumpi Daniel,
Fröhlich Johannes,
Kuntner Claudia,
Mikula Hannes
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406154
Subject(s) - bioorthogonal chemistry , tetrazine , molecular imaging , chemistry , pet imaging , positron emission tomography , in vivo , combinatorial chemistry , nanotechnology , click chemistry , nuclear medicine , materials science , medicine , organic chemistry , biology , microbiology and biotechnology
Bioorthogonal PET probes serve as highly valuable tools in the field of pretargeted molecular imaging. In their Communication on page 9655 ff., H. Mikula, C. Kuntner, and co‐workers describe the development, synthesis, and characterization of a low‐molecular‐weight 18 F‐labeled tetrazine derivative that can be used for bioorthogonal PET imaging of dienophile‐tagged (bio)molecules through the application of in vivo chemistry.