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Back Cover: Antagonizing STAT3 Dimerization with a Rhodium(III) Complex (Angew. Chem. Int. Ed. 35/2014)
Author(s) -
Ma DikLung,
Liu LiJuan,
Leung KaHo,
Chen YenTing,
Zhong HaiJing,
Chan Daniel ShiuHin,
Wang HuiMin David,
Leung ChungHang
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201406152
Subject(s) - rhodium , stat3 , activator (genetics) , chemistry , stat protein , in vivo , sh2 domain , front cover , int , stereochemistry , cover (algebra) , signal transduction , catalysis , biochemistry , biology , proto oncogene tyrosine protein kinase src , receptor , computer science , engineering , microbiology and biotechnology , operating system , mechanical engineering
STAT3 dimerization can be directly inhibited by a substitutionally inert, Group 9 organometallic compound, as D.‐L. Ma, C.‐H. Leung, H.‐M. D. Wang, and co‐workers report in their Communication on page 9178 ff. The cyclometalated rhodium(III) complex targets the SH2 domain of STAT3 (signal transducer and activator of transcription 3), and exhibits potent anticancer activity against melanoma xenograft in an in vivo mouse model.