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Au@Pt Nanoparticle Encapsulated Target‐Responsive Hydrogel with Volumetric Bar‐Chart Chip Readout for Quantitative Point‐of‐Care Testing
Author(s) -
Zhu Zhi,
Guan Zhichao,
Jia Shasha,
Lei Zhichao,
Lin Shuichao,
Zhang Huimin,
Ma Yanli,
Tian ZhongQun,
Yang Chaoyong James
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201405995
Subject(s) - point of care testing , bar (unit) , software portability , nanotechnology , materials science , chip , point of care , analyte , computer science , biomedical engineering , chemistry , chromatography , engineering , physics , medicine , telecommunications , nursing , meteorology , immunology , biology , programming language
Point‐of‐care testing (POCT) with the advantages of speed, simplicity, portability, and low cost is critical for the measurement of analytes in a variety of environments where access to laboratory infrastructure is lacking. While qualitative POCTs are widely available, quantitative POCTs present significant challenges. Here we describe a novel method that integrates an Au core/Pt shell nanoparticle (Au@PtNP) encapsulated target‐responsive hydrogel with a volumetric bar‐chart chip (V‐Chip) for quantitative POCT. Upon target introduction, the hydrogel immediately dissolves and releases Au@PtNPs, which can efficiently catalyze the decomposition of H 2 O 2 to generate a large volume of O 2 to move of an ink bar in the V‐Chip. The concentration of the target introduced can be visually quantified by reading the traveling distance of the ink bar. This method has the potential to be used for portable and quantitative detection of a wide range of targets without any external instrument.