Premium
Reversible Supramolecular Assembly at Specific DNA Sites: Nickel‐Promoted Bivalent DNA Binding with Designed Peptide and Bipyridyl–Bis(benzamidine) Components
Author(s) -
Sánchez Mateo I.,
Mosquera Jesús,
Vázquez M. Eugenio,
Mascareñas José L.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201405726
Subject(s) - benzamidine , supramolecular chemistry , dna , chemistry , bivalent (engine) , peptide , nickel , combinatorial chemistry , histidine , stereochemistry , crystallography , biochemistry , metal , organic chemistry , enzyme , crystal structure
At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)‐modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA‐binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.