Premium
Membrane‐Spanning DNA Nanopores with Cytotoxic Effect
Author(s) -
Burns Jonathan R.,
AlJuffali Noura,
Janes Sam M.,
Howorka Stefan
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201405719
Subject(s) - nanopore , membrane , dna , cancer cell , microbiology and biotechnology , nanotechnology , biophysics , cytotoxic t cell , biomedicine , chemistry , cancer , materials science , biology , biochemistry , in vitro , bioinformatics , genetics
DNA‐based cytotoxic agents : Nanopores composed of folded DNA featuring a hydrophobic belt of ethyl phosphorothioate groups insert into bilayer membranes and kill cancer cells (see picture). The mode by which the pores achieve cell killing is elucidated with confocal microscopy.