Cysteine‐Selective Reactions for Antibody Conjugation | Zendy

Cal Pedro M. S. D. | Zendy; Bernardes Gonçalo J. L. | Zendy; Gois Pedro M. P. | Zendy

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Cysteine‐Selective Reactions for Antibody Conjugation

Author(s) -

Cal Pedro M. S. D.,

Bernardes Gonçalo J. L.,

Gois Pedro M. P.

Publication year - 2014

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201405702

Subject(s) - maleimide , bioconjugation , succinimide , cysteine , thioether , conjugate , chemistry , homogeneous , combinatorial chemistry , biochemistry , organic chemistry , enzyme , mathematical analysis , physics , mathematics , thermodynamics

Moving tracks from maleimide : New site‐selective protein modification reactions at cysteine have been developed. Unlike conventional maleimide conjugation, which results in a labile thioether succinimide, the new bioconjugation reactions result in stable conjugates and provide opportunities to develop a new generation of homogeneous, stable, and therapeutically useful conjugates.

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