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Cysteine‐Selective Reactions for Antibody Conjugation
Author(s) -
Cal Pedro M. S. D.,
Bernardes Gonçalo J. L.,
Gois Pedro M. P.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201405702
Subject(s) - maleimide , bioconjugation , succinimide , cysteine , thioether , conjugate , chemistry , homogeneous , combinatorial chemistry , biochemistry , organic chemistry , enzyme , mathematical analysis , physics , mathematics , thermodynamics
Moving tracks from maleimide : New site‐selective protein modification reactions at cysteine have been developed. Unlike conventional maleimide conjugation, which results in a labile thioether succinimide, the new bioconjugation reactions result in stable conjugates and provide opportunities to develop a new generation of homogeneous, stable, and therapeutically useful conjugates.