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Aldehyde‐Assisted Ruthenium(II)‐Catalyzed CH Oxygenations
Author(s) -
Yang Fanzhi,
Rauch Karsten,
Kettelhoit Katharina,
Ackermann Lutz
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201405647
Subject(s) - chemoselectivity , ruthenium , substrate (aquarium) , aldehyde , chemistry , metalation , scope (computer science) , combinatorial chemistry , catalysis , organic chemistry , computer science , biology , ecology , programming language
Versatile ruthenium(II) complexes allow for site‐selective CH oxygenations with weakly‐coordinating aldehydes. The challenging CH functionalizations proceed with high chemoselectivity by rate‐determining CH metalation. The new method features an ample substrate scope, which sets the stage for the step‐economical preparation of various bioactive heterocycles.