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Enantioselective Formation of All‐Carbon Quaternary Stereocenters from Indoles and Tertiary Alcohols Bearing A Directing Group
Author(s) -
Zhao Wanxiang,
Wang Zhaobin,
Chu Boyang,
Sun Jianwei
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201405252
Subject(s) - stereocenter , enantioselective synthesis , steric effects , intermolecular force , catalysis , chemistry , group (periodic table) , indole test , quaternary carbon , tertiary alcohols , organic chemistry , stereochemistry , combinatorial chemistry , molecule
Described is an efficient catalytic asymmetric intermolecular CC bond‐formation process to generate acyclic all‐carbon quaternary stereocenters. The reactions overcome the unfavorable steric hindrance around reactive centers, and the competitive elimination (E1), to form a range of useful indole products with excellent efficiency and enantioselectivity.