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Catalyst‐Dependent Divergent Synthesis of Pyrroles from 3‐Alkynyl Imine Derivatives: A Noncarbonylative and Carbonylative Approach
Author(s) -
Chen GenQiang,
Zhang XiaoNan,
Wei Yin,
Tang XiangYing,
Shi Min
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201405215
Subject(s) - carbenoid , imine , cycloisomerization , chemistry , reagent , pyrrole , catalysis , combinatorial chemistry , ruthenium , ligand (biochemistry) , medicinal chemistry , organic chemistry , rhodium , biochemistry , receptor
A novel Ru 0 ‐ and Rh I ‐catalyzed noncarbonylative and carbonylative cycloisomerization of readily available 3‐alkynyl imine derivatives has been developed to provide 3,4‐fused or nonfused pyrrole derivatives efficiently in moderate to excellent yields. The key steps involve the formation of a ruthenium carbenoid intermediate or a rhodacycle intermediate, respectively. In these reactions, CO can serve as a ligand or a reagent.