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Easily Accessible Auxiliary for Palladium‐Catalyzed Intramolecular Amination of C(sp 2 )H and C(sp 3 )H Bonds at δ‐ and ε‐Positions
Author(s) -
Wang Chao,
Chen Changpeng,
Zhang Jingyu,
Han Jian,
Wang Qian,
Guo Kun,
Liu Pei,
Guan Mingyu,
Yao Yingming,
Zhao Yingsheng
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201404854
Subject(s) - amination , palladium , intramolecular force , catalysis , chemistry , denticity , surface modification , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , crystal structure
An easily synthesized and accessible N,O‐bidentate auxiliary has been developed for selective CH activation under palladium catalysis. The novel auxiliary showed its first powerful application in CH functionalization of remote positions. Both C(sp 2 )H and C(sp 3 )H bonds at δ‐ and ε‐positions were effectively activated, thus giving tetrahydroquinolines, benzomorpholines, pyrrolidines, and indolines in moderate to excellent yields by palladium‐catalyzed intramolecular CH amination.