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Selection of DNA‐Encoded Small Molecule Libraries Against Unmodified and Non‐Immobilized Protein Targets
Author(s) -
Zhao Peng,
Chen Zitian,
Li Yizhou,
Sun Dawei,
Gao Yuan,
Huang Yanyi,
Li Xiaoyu
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201404830
Subject(s) - dna , drug discovery , selection (genetic algorithm) , computational biology , chemistry , small molecule , combinatorial chemistry , ligand (biochemistry) , biology , nanotechnology , biochemistry , computer science , materials science , receptor , artificial intelligence
The selection of DNA‐encoded libraries against biological targets has become an important discovery method in chemical biology and drug discovery, but the requirement of modified and immobilized targets remains a significant disadvantage. With a terminal protection strategy and ligand‐induced photo‐crosslinking, we show that iterated selections of DNA‐encoded libraries can be realized with unmodified and non‐immobilized protein targets.