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Cobalt‐Catalyzed, Aminoquinoline‐Directed C(sp 2 )H Bond Alkenylation by Alkynes
Author(s) -
Grigorjeva Liene,
Daugulis Olafs
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201404579
Subject(s) - catalysis , cobalt , chemistry , medicinal chemistry , functional group , oxygen , coupling (piping) , combinatorial chemistry , polymer chemistry , organic chemistry , materials science , metallurgy , polymer
A method for cobalt‐catalyzed, aminoquinoline‐ and picolinamide‐directed C(sp 2 )H bond alkenylation by alkynes was developed. The method shows excellent functional‐group tolerance and both internal and terminal alkynes are competent substrates for the coupling. The reaction employs a Co(OAc) 2 ⋅4 H 2 O catalyst, Mn(OAc) 2 co‐catalyst, and oxygen (from air) as a terminal oxidant.