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Mild and Versatile Nitrate‐Promoted CH Bond Fluorination
Author(s) -
Lou ShaoJie,
Xu DanQian,
Xu ZhenYuan
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201404423
Subject(s) - nitrate , bond , chemistry , combinatorial chemistry , organic chemistry , business , finance
A novel and facile CH bond fluorination proceeds under remarkably mild conditions (close to room temperature in most cases). Both aromatic and olefinic C(sp 2 )H bonds with a wide range of electronic properties are selectively fluorinated in the presence of a catalytic amount of simple, cheap, and nontoxic nitrate as the promoter. A Pd II /Pd IV catalytic cycle that is initiated by an in situ generated cationic [Pd(NO 3 )] + species was proposed based on preliminary mechanistic studies.