Premium
Inside Back Cover: Direct Umpolung of Glycals and Related 2,3‐Unsaturated N ‐Acetylneuraminic Acid Derivatives Using Samarium Diiodide (Angew. Chem. Int. Ed. 24/2014)
Author(s) -
Le Tien Xuan,
Papin Caroline,
Doisneau Gilles,
Beau JeanMarie
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201404338
Subject(s) - umpolung , chemistry , samarium diiodide , samarium , nucleophile , metalation , medicinal chemistry , organic chemistry , stereochemistry , catalysis
One hundred years ago while exploring the reductive metalation of “Acetobromglucose” with zinc, Emil Fischer discovered the glycals. Since that time, these very useful unsaturated carbohydrates have been extensively used for the preparation of important complex carbohydrates and natural products following the natural electrophilic route. In their Communication on page 6184 ff., G. Doisneau, J.‐M. Beau et al. reveal a new nucleophilic route by direct and selective umpolung using samarium diiodide.