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Cover Picture: Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran (Angew. Chem. Int. Ed. 26/2014)
Author(s) -
Wang Z. Jane,
Renata Hans,
Peck Nicole E.,
Farwell Christopher C.,
Coelho Pedro S.,
Arnold Frances H.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201404337
Subject(s) - enantioselective synthesis , carbenoid , chemistry , ligand (biochemistry) , cyclopropanation , stereochemistry , catalysis , organic chemistry , rhodium , biochemistry , receptor
Mutation of the axial ligand can be used to tune the carbenoid activity of cytochrome P450 from Bacillus megaterium. In their Communication on page 6810 ff. , F. Arnold and co‐workers report the engineering of a histidine‐ligated P450 enzyme that shows high catalytic activity for in vivo cyclopropanation using diazo compounds. This enzyme enables the enantioselective synthesis of a key precursor of levomilnacipran under aerobic conditions on a preparative scale. Image: Liang Zong and Yan Liang (L2Molecule.com).