Premium
Synchronization of Two Assembly Processes To Build Responsive DNA Nanostructures
Author(s) -
Nie Zhou,
Wang Pengfei,
Tian Cheng,
Mao Chengde
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201404307
Subject(s) - nanostructure , dna nanotechnology , nanotechnology , dna , materials science , synchronization (alternating current) , self assembly , isothermal process , topology (electrical circuits) , chemistry , physics , engineering , electrical engineering , biochemistry , thermodynamics
Herein, we report a strategy for the synchronization of two self‐assembly processes to assemble stimulus‐responsive DNA nanostructures under isothermal conditions. We hypothesized that two independent assembly processes, when brought into proximity in space, could be synchronized and would exhibit positive synergy. To demonstrate this strategy, we assembled a ladderlike DNA nanostructure and a ringlike DNA nanostructure through two hybridization chain reactions (HCRs) and an HCR in combination with T‐junction cohesion, respectively. Such proximity‐induced synchronization adds a new element to the tool box of DNA nanotechnology. We believe that it will be a useful approach for the assembly of complex and responsive nanostructures.