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The CH Activation/1,3‐Diyne Strategy: Highly Selective Direct Synthesis of Diverse Bisheterocycles by Rh III Catalysis
Author(s) -
Yu DaGang,
de Azambuja Francisco,
Gensch Tobias,
Daniliuc Constantin G.,
Glorius Frank
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201403782
Subject(s) - selectivity , catalysis , chemistry , combinatorial chemistry , reactivity (psychology) , transition metal , stereochemistry , organic chemistry , medicine , alternative medicine , pathology
The reactivity and selectivity of 1,3‐diynes in transition‐metal‐catalyzed CH activation is exploited to quickly assemble diverse polysubstituted bisheterocycles, which are highly important but difficult to access. By using the CH activation/1,3‐diyne strategy, we overcame the challenges of selectivity (chemo‐, regio‐, and mono‐/diannulation) and constructed seven kinds of adjacent bisheterocycles through the formation of four strategic bonds with high efficiency and high selectivity.