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Formation of Four Different Aromatic Scaffolds from Nitriles through Tandem Divergent Catalysis
Author(s) -
Kim Ju Hyun,
Bouffard Jean,
Lee Sanggi
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201403698
Subject(s) - reagent , catalysis , chemistry , palladium , tandem , combinatorial chemistry , bromide , zinc bromide , zinc , solvent , organic chemistry , materials science , composite material
A zinc bromide complex, formed by the sequential reaction of nitriles with a Reformatsky reagent and terminal alkynes, is used as an intermediate for divergent palladium‐catalyzed reactions. The reaction pathway of the intermediate is precisely controlled by the choice of the reaction solvent or the palladium catalyst to quickly form four different aromatic scaffolds—arylamines, aminoindenes, pyrroles, and quinolines—starting from readily available nitriles.