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Synthetic Disialyl Hexasaccharides Protect Neonatal Rats from Necrotizing Enterocolitis
Author(s) -
Yu Hai,
Lau Kam,
Thon Vireak,
Autran Chloe A.,
JantscherKrenn Evelyn,
Xue Mengyang,
Li Yanhong,
Sugiarto Go,
Qu Jingyao,
Mu Shengmao,
Ding Li,
Bode Lars,
Chen Xi
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201403588
Subject(s) - necrotizing enterocolitis , monosaccharide , disaccharide , medicine , chemistry , biochemistry
Two novel synthetic α2–6‐linked disialyl hexasaccharides, disialyllacto‐ N ‐neotetraose (DSLNnT) and α2–6‐linked disialyllacto‐ N ‐tetraose (DS′LNT), were readily obtained by highly efficient one‐pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS′LNT were shown to protect neonatal rats from necrotizing enterocolitis (NEC) and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC in preterm infants.