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Coordination‐Driven Folding and Assembly of a Short Peptide into a Protein‐like Two‐Nanometer‐Sized Channel
Author(s) -
Sawada Tomohisa,
Matsumoto Asami,
Fujita Makoto
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201403506
Subject(s) - polyproline helix , peptide , crystallography , molecule , folding (dsp implementation) , self assembly , ligand (biochemistry) , nanometre , materials science , chemistry , nanotechnology , organic chemistry , receptor , biochemistry , electrical engineering , engineering , composite material
Short peptide helices have attracted attention as suitable building blocks for soft functional materials, but they are rarely seen in crystalline materials. A new artificial nanoassembly of short peptide helices in the crystalline state is presented in which peptide helices are arranged three‐dimensionally by metal coordination. The folding and assembly processes of a short peptide ligand containing the Gly‐Pro‐Pro sequence were induced by silver(I) coordination in aqueous alcohol, and gave rise to a single crystal composed of polyproline II helices. Crystallographic studies revealed that this material possesses two types of unique helical nanochannel; the larger channel measures more than 2 nm in diameter. Guest uptake properties were investigated by soaking the crystals in polar solutions of guest molecules; anions, organic chiral molecules, and bio‐oligomers are effectively encapsulated by this peptide‐folded porous crystal, with moderate to high chiral recognition for chiral molecules.