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Self‐Assembly of DNA–Oligo( p ‐phenylene‐ethynylene) Hybrid Amphiphiles into Surface‐Engineered Vesicles with Enhanced Emission
Author(s) -
Albert Shine K.,
Thelu Hari Veera Prasad,
Golla Murali,
Krishnan Nithiyanandan,
Chaudhary Soma,
Varghese Reji
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201403455
Subject(s) - vesicle , nanotechnology , supramolecular chemistry , dna nanotechnology , amphiphile , conjugated system , materials science , click chemistry , nanostructure , nanoelectronics , self assembly , dna origami , förster resonance energy transfer , chromophore , dna , chemistry , fluorescence , molecule , membrane , polymer , copolymer , photochemistry , organic chemistry , polymer chemistry , biochemistry , physics , quantum mechanics , composite material
Surface‐addressable nanostructures of linearly π‐conjugated molecules play a crucial role in the emerging field of nanoelectronics. Herein, by using DNA as the hydrophilic segment, we demonstrate a solid‐phase “click” chemistry approach for the synthesis of a series of DNA–chromophore hybrid amphiphiles and report their reversible self‐assembly into surface‐engineered vesicles with enhanced emission. DNA‐directed surface addressability of the vesicles was demonstrated through the integration of gold nanoparticles onto the surface of the vesicles by sequence‐specific DNA hybridization. This system could be converted to a supramolecular light‐harvesting antenna by integrating suitable FRET acceptors onto the surface of the nanostructures. The general nature of the synthesis, surface addressability, and biocompatibility of the resulting nanostructures offer great promises for nanoelectronics, energy, and biomedical applications.