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Towards High‐Performance Lewis Acid Organocatalysis
Author(s) -
Ratjen Lars,
van Gemmeren Manuel,
Pesciaioli Fabio,
List Benjamin
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201402765
Subject(s) - organocatalysis , enantioselective synthesis , lewis acids and bases , catalysis , hydrogen bond , chemistry , hydrogen bond catalysis , combinatorial chemistry , organic chemistry , molecule
The combination of Lewis acid organocatalysis and internal hydrogen‐bond assistance was used to develop a new type of highly active disulfonimide catalyst. The increased Lewis acidity was documented by activity comparisons as well as theoretical investigations. Finally, the potential of the hydrogen‐bond‐assisted disulfonimide catalyst was demonstrated by its application in an enantioselective transformation.