Access to Oxoquinoline Heterocycles by N‐Heterocyclic Carbene Catalyzed Ester Activation for Selective Reaction with an Enone | Zendy

Fu Zhenqian | Zendy; Jiang Ke | Zendy; Zhu Tingshun | Zendy; Torres Jaume | Zendy; Chi Yonggui Robin | Zendy

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Access to Oxoquinoline Heterocycles by N‐Heterocyclic Carbene Catalyzed Ester Activation for Selective Reaction with an Enone

Author(s) -

Fu Zhenqian,

Jiang Ke,

Zhu Tingshun,

Torres Jaume,

Chi Yonggui Robin

Publication year - 2014

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201402620

Subject(s) - carbene , catalysis , chemistry , enone , cascade reaction , enantiomer , atom economy , carbon atom , combinatorial chemistry , organic chemistry , medicinal chemistry , ring (chemistry)

Organocatalytic ester activation is developed for a highly selective cascade reaction between saturated esters and amino enones. The reaction involves activation of the β‐carbon atom of the ester as a key step. This method allows a single‐step access to multicyclic oxoquinoline‐type heterocycles with high enantiomeric ratios.

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