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Access to Oxoquinoline Heterocycles by N‐Heterocyclic Carbene Catalyzed Ester Activation for Selective Reaction with an Enone
Author(s) -
Fu Zhenqian,
Jiang Ke,
Zhu Tingshun,
Torres Jaume,
Chi Yonggui Robin
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201402620
Subject(s) - carbene , catalysis , chemistry , enone , cascade reaction , enantiomer , atom economy , carbon atom , combinatorial chemistry , organic chemistry , medicinal chemistry , ring (chemistry)
Organocatalytic ester activation is developed for a highly selective cascade reaction between saturated esters and amino enones. The reaction involves activation of the β‐carbon atom of the ester as a key step. This method allows a single‐step access to multicyclic oxoquinoline‐type heterocycles with high enantiomeric ratios.