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Palladium‐Catalyzed C(sp 3 )H Activation: A Facile Method for the Synthesis of 3,4‐Dihydroquinolinone Derivatives
Author(s) -
Yan JiaXuan,
Li Hu,
Liu XiangWei,
Shi JiangLing,
Wang Xin,
Shi ZhangJie
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201402562
Subject(s) - catalysis , palladium , catalytic cycle , inert , chemistry , ligand (biochemistry) , oxidative addition , oxidative phosphorylation , inert gas , medicinal chemistry , combinatorial chemistry , organic chemistry , biochemistry , receptor
3,4‐Dihydroquinolinones were synthesized by the palladium‐catalyzed, oxidative‐addition‐initiated activation and arylation of inert C(sp 3 )H bonds. Pd(OAc) 2 and P( o ‐tol) 3 were used as the catalyst and ligand, respectively, to improve the efficiency of the reaction. A further advantage of this reaction is that it could be performed in air. A relatively rare seven‐membered palladacycle was proposed as a key intermediate of the catalytic cycle.