Catching Bubbles: Targeting Ultrasound Microbubbles Using Bioorthogonal Inverse‐Electron‐Demand Diels–Alder Reactions | Zendy

Zlitni Aimen | Zendy; Janzen Nancy | Zendy; Foster F. Stuart | Zendy; Valliant John F. | Zendy

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Catching Bubbles: Targeting Ultrasound Microbubbles Using Bioorthogonal Inverse‐Electron‐Demand Diels–Alder Reactions

Author(s) -

Zlitni Aimen,

Janzen Nancy,

Foster F. Stuart,

Valliant John F.

Publication year - 2014

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201402473

Subject(s) - bioorthogonal chemistry , microbubbles , tetrazine , on demand , computer science , ultrasound , chemistry , nanotechnology , combinatorial chemistry , materials science , click chemistry , medicine , radiology , multimedia , organic chemistry

Catching bubbles : Tetrazine‐functionalized microbubbles were prepared for use as ultrasound contrast agents, and shown to selectively localize on cells labeled with a TCO‐derivatized antibody against VEGFR2. This capture approach based on labeling and bioorthogonal chemistry was validated in a flow‐chamber assay and in vivo through ultrasound imaging of VEGFR2‐positive and VEGFR2‐negative murine tumor models. TCO= trans ‐cyclooctene.

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