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The Hexadehydro‐Diels–Alder Reaction: A New Chapter in Aryne Chemistry
Author(s) -
Holden née Hall Catherine,
Greaney Michael F.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201402405
Subject(s) - aryne , intramolecular force , cycloaddition , chemistry , pericyclic reaction , atom economy , nucleophile , computational chemistry , reagent , organic chemistry , combinatorial chemistry , catalysis
Arynes are now accessible through the [4+2] Diels–Alder cycloaddition of triynes, a process that captures all atoms of the starting material in the aryne product. The atom economy and reagent‐free conditions provide a new dimension to aryne chemistry and should enable exciting developments in the study and application of arynes in synthesis.