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1958 – 2014: After 56 Years of Research, Cytochrome P450 Reactivity Is Finally Explained
Author(s) -
McQuarters Ashley B.,
Wolf Matthew W.,
Hunt Andrew P.,
Lehnert Nicolai
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201402404
Subject(s) - reactivity (psychology) , catalytic cycle , enzyme , cytochrome p450 , chemistry , cytochrome , stereochemistry , mechanism (biology) , biochemistry , computational chemistry , epistemology , philosophy , medicine , pathology , alternative medicine
Nature's wisdom in enzyme design : Compounds I and II in the catalytic cycle of the Cytochrome P450 enzymes have been trapped and characterized recently. This work has provided further insight into the electronic structure and reactivity of these crucial intermediates, and key questions regarding the mechanism of these enzymes have finally been answered.