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Phosphine‐ and Hydrogen‐Free: Highly Regioselective Ruthenium‐Catalyzed Hydroaminomethylation of Olefins
Author(s) -
Gülak Samet,
Wu Lipeng,
Liu Qiang,
Franke Robert,
Jackstell Ralf,
Beller Matthias
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201402368
Subject(s) - regioselectivity , hydroformylation , chemoselectivity , chemistry , ruthenium , phosphine , imine , catalysis , ligand (biochemistry) , organic chemistry , enamine , combinatorial chemistry , dehydrogenation , rhodium , biochemistry , receptor
A highly regioselective ruthenium‐catalyzed hydroaminomethylation of olefins is reported. Using easily available trirutheniumdodecacarbonyl an efficient sequence consisting of a water‐gas shift reaction, hydroformylation of olefins, with subsequent imine or enamine formation and final reduction is realized. This novel procedure is highly practical (ligand‐free, one pot) and economic (low catalyst loading and inexpensive metal). Bulk industrial as well as functionalized olefins react with various amines to give the corresponding tertiary amines generally in high yields (up to 92 %), excellent regioselectivities ( n / iso >99:1), and full chemoselectivity in favor of terminal olefins.