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In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites
Author(s) -
Wang YiXiang J.,
Zhu XiaoMing,
Liang Qi,
Cheng Christopher H. K.,
Wang Wei,
Leung Ken ChamFai
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201402144
Subject(s) - in vivo , nanoshell , doxorubicin , vinyl alcohol , materials science , magnetic resonance imaging , superparamagnetism , liver tumor , drug delivery , composite number , mri contrast agent , biomedical engineering , iron oxide , nanoparticle , nanotechnology , cancer research , medicine , composite material , magnetic field , radiology , hepatocellular carcinoma , chemotherapy , surgery , metallurgy , physics , microbiology and biotechnology , magnetization , quantum mechanics , biology , polymer
A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an in vivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent.