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Cover Picture: Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry (Angew. Chem. Int. Ed. 36/2014)
Author(s) -
Dong Jiajia,
Krasnova Larissa,
Finn M. G.,
Sharpless K. Barry
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201401157
Subject(s) - chemistry , heteroatom , click chemistry , silyl ether , acceptor , molecule , silylation , crystallography , polymer chemistry , organic chemistry , ring (chemistry) , catalysis , physics , condensed matter physics
A completely new click chemistry is described by K. B. Sharpless, M. G. Finn, and co‐workers in their Review on page 9430 ff. The robust bond between S VI and F atoms (such as in the gas SO 2 F 2 and Michael acceptor HCCHSO 2 F) can be specifically activated by proton (often in the form of the bifluoride ion, HF 2 − ) or silicon centers (e.g. an aryl silyl ether) to create S–heteroatom linkages of surprising stability. Applications of this click 2.0 method to the synthesis of small molecules or polymers (see the Communication by K. B. Sharpless, V. V. Fokin et al. on page 9466 ff. ), and the modification of biomolecules—each represented at the periphery of the image—are discussed.