Premium
Back Cover: Regulated Incorporation of Two Different Metal Ions into Programmed Sites in a Duplex by DNA Polymerase Catalyzed Primer Extension (Angew. Chem. Int. Ed. 26/2014)
Author(s) -
Funai Tatsuya,
Nakamura Junko,
Miyazaki Yuki,
Kiriu Risa,
Nakagawa Osamu,
Wada Shunichi,
Ono Akira,
Urata Hidehito
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201401152
Subject(s) - duplex (building) , primer (cosmetics) , primer extension , dna , nucleotide , dna polymerase , chemistry , base pair , dna polymerase beta , polymerase , metal ions in aqueous solution , microbiology and biotechnology , ion , stereochemistry , biology , biochemistry , base sequence , base excision repair , dna damage , gene , organic chemistry
Hg II and Ag I ions were found to specifically trigger DNA polymerase catalyzed primer extension in the absence of a Watson–Crick matched nucleotide through the formation of the T–Hg II –T and newly discovered C–Ag I –T base pairs. In their Communication on page 6624 ff., H. Urata and co‐workers show that the strict base recognition of these metal ions enables the regulated incorporation of the two different metal ions into programmed sites in the DNA duplex.