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Cover Picture: Cytoskeletal Actin Dynamics are Involved in Pitch‐Dependent Neurite Outgrowth on Bead Monolayers (Angew. Chem. Int. Ed. 24/2014)
Author(s) -
Kang Kyungtae,
Yoon Seo Young,
Choi SungEun,
Kim MiHee,
Park Matthew,
Nam Yoonkey,
Lee Jin Seok,
Choi Insung S.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201401146
Subject(s) - neurite , cytoskeleton , actin , hippocampal formation , biophysics , chemistry , bead , materials science , cell , biochemistry , biology , neuroscience , in vitro , composite material
Pitch‐dependent neurite outgrowth was demonstrated in primary hippocampal neurons on monolayers of silica beads. In their Communication on page 6075 ff., Y. Nam, J. S. Lee, I. S. Choi, and co‐workers report that neurite outgrowth is accelerated on larger beads (white) compared to smaller beads (black) up to a bead diameter of approximately 1 μm. Biochemical analysis indicated that cytoskeletal actin dynamics are primarily responsible for the recognition of surface topography.