Premium
Back Cover: Sequential Intra‐Intercellular Nanoparticle Delivery System for Deep Tumor Penetration (Angew. Chem. Int. Ed. 24/2014)
Author(s) -
Ju Caoyun,
Mo Ran,
Xue Jingwei,
Zhang Lei,
Zhao Zekai,
Xue Lingjing,
Ping Qineng,
Zhang Can
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201401142
Subject(s) - internalization , nanogel , penetration (warfare) , nanoparticle , delivery system , biophysics , intracellular , tumor cells , nanotechnology , cancer cell , chemistry , materials science , cancer research , drug delivery , cancer , biomedical engineering , biology , cell , medicine , biochemistry , engineering , operations research , genetics
A nanoparticle delivery system enables deep tumor penetration. As R. Mo, C. Zhang et al. show in their Communication on page 6253 ff., pH‐sensitive nanogels (small yellow spheres) accumulate at the tumor tissues (red cells). After internalization, the nanogels swell (large spheres) releasing the encapsulated chemotherapeutics (blue). The nanogel contracts (small yellow spheres), is liberated from the dead cells (grape‐like cells), infects neighboring cancer cells nearer the center of the tumor, and the process is repeated.