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Cover Picture: A New Pathway of DNA G‐Quadruplex Formation (Angew. Chem. Int. Ed. 19/2014)
Author(s) -
Čeru Slavko,
Šket Primož,
Prislan Iztok,
Lah Jurij,
Plavec Janez
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201401133
Subject(s) - guanine , g quadruplex , dna , chemistry , stereochemistry , cover (algebra) , crystallography , nucleotide , biochemistry , gene , mechanical engineering , engineering
Guanine‐rich DNA sequences can self‐assemble into specific pre‐organized DNA structures, where two‐by‐two guanine residues shown as “duets” are involved in GG N1‐carbonyl symmetric base pairs. In their Communication on page 4881 ff., J. Lah, J. Plavec, and co‐workers demonstrate the transition of these “duets” into guanine‐quartets, presented as a “string quartet” when interacting with cations, such as potassium ions. This rearrangement consequently leads to formation of G‐quadruplex structures.