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Back Cover: Phenotypic Screening to Identify Small‐Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy (Angew. Chem. Int. Ed. 20/2014)
Author(s) -
Koh Minseob,
Park Jongmin,
Koo Ja Young,
Lim Donghyun,
Cha Mi Young,
Jo Ala,
Choi Jang Hyun,
Park Seung Bum
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201401129
Subject(s) - small molecule , phenotype , phenotypic screening , drug discovery , computational biology , enhancer , identification (biology) , biology , bioinformatics , genetics , gene , transcription factor , botany
The phenotype‐based discovery of novel therapeutic agents has suffered from the lengthy process of target deconvolution. In their Communication on page 5102 ff., S. B. Park et al. show that the convergent strategy of phenotype screening with early stage target identification can bridge the gap between phenotype‐based hit discovery and rational drug discovery to generate a new class of therapeutic agents. They were able to identify a new small‐molecule enhancer of cellular glucose uptake that targets PPARγ.