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Cover Picture: An Efficient and Modular Route to Sequence‐Defined Polymers Appended to DNA (Angew. Chem. Int. Ed. 18/2014)
Author(s) -
Edwardson Thomas G. W.,
Carneiro Karina M. M.,
Serpell Christopher J.,
Sleiman Hanadi F.
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201401123
Subject(s) - phosphoramidite , polymer , monomer , materials science , amphiphile , sequence (biology) , copolymer , dna , crystallography , chemistry , oligonucleotide , biochemistry , composite material
Sequence‐controlled polymers attached to DNA can be prepared by solid‐phase phosphoramidite coupling, as H. F. Sleiman, C. J. Serpell, and co‐workers report in their Communication on page 4567 ff. Polymers with the same molecular composition but different monomer patterns exhibit different amphiphilic self‐assembly. As the DNA component still retains base‐pairing fidelity, these novel conjugates encode information in two distinct, and orthogonal, assembly languages.