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Inside Back Cover: A Convergent Total Synthesis of the Telomerase Inhibitor (±)‐γ‐Rubromycin (Angew. Chem. Int. Ed. 17/2014)
Author(s) -
Wilsdorf Michael,
Reissig HansUlrich
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201401119
Subject(s) - int , total synthesis , natural product , silylation , cover (algebra) , silicon , chemistry , block (permutation group theory) , stereochemistry , combinatorial chemistry , computer science , mathematics , organic chemistry , combinatorics , engineering , catalysis , mechanical engineering , operating system
Silicon in, silicon out could be the caption for the convergent total synthesis of the telomerase inhibitor (±)‐γ‐rubromycin reported by M. Wilsdorf and H.‐U. Reissig in their Communication on page 4332 ff. They combine three highly functionalized building blocks through selective organometallic chemistry and a silyl‐substituted C 3 building block plays a key role. Three acid‐promoted reactions serve to generate the sensitive spiroketal natural product under desilylation. Graphic courtesy of Dr. Daniel Trawney.